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AIDS is mainly a sexually transmitted disease, and accordingly, mucosal tissues are the primary sites of natural human immunodeficiency virus type-1 (HIV-1) transmission. Mucosal immunoglobulin A (IgA) antibody specific for HIV-1 envelope gp41 subunit is one correlate of protection in individuals who are highly sexually exposed to HIV-1 but remain(More)
Natural antibodies to gp41 inhibit HIV-1 replication through the recognition of two different regions, corresponding to the leucine zipper motif in the HR1 alpha-helix and to another motif within HR2 region, hosting 2F5 and 4E10 epitope. This study aimed at reproducing such protective responses through VLP vaccination. Six regions covering the alpha-helical(More)
Background AIDS is mainly a sexually transmitted disease and accordingly, mucosal tissues are the primary sites of natural HIV1 transmission. Mucosal IgA antibody specific for HIV-1 envelope gp41-subunit is one correlate of protection in individuals who are highly sexually exposed to HIV-1 but remain persistently IgG seronegative (HEPS). Understanding these(More)
Methods We have developed a mucosal vaccine candidate based on two complementary conserved gp41 subunit antigensa trimeric recombinant gp41 deleted in known immunodominant regions (rGp41) and the 35 amino acid peptide P1, this later adopting the 3D conformation of the gp41 MPER and target of HIV-neutralizing IgA in highly exposed but persistently(More)
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