A. Rita Gaio

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Studies on 3,4-methylenedioxymethamphetamine ("ecstasy")-induced neurotoxicity mainly focus on damage of serotonergic terminals. Less attention has been given to neuronal cell death produced by 3,4-methylenedioxymethamphetamine and other amphetamines in areas including the cortex, striatum and thalamus. In the present study we investigated(More)
We study pseudoholomorphic curves in symplectic quotients as adiabatic limits of solutions to the symplectic vortex equations. Our main theorem asserts that the genus zero invariants of Hamiltonian group actions defined by these equations are related to the genus zero Gromov–Witten invariants of the symplectic quotient (in the monotone case) via a natural(More)
In this paper we define invariants of Hamiltonian group actions for central regular values of the moment map. The key hypotheses are that the moment map is proper and that the ambient manifold is symplectically aspherical. The invariants are based on the symplectic vortex equations. Applications include an existence theorem for relative periodic orbits, a(More)
3 Invariants of Hamiltonian group actions 17 3.1 An action functional . . . . . . . . . . . . . . . . . . . . . . . 17 3.2 Symplectic reduction . . . . . . . . . . . . . . . . . . . . . . . 19 3.3 Hamiltonian perturbations . . . . . . . . . . . . . . . . . . . . 24 3.4 Moduli spaces . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.5 Fredholm(More)
P-glycoprotein (P-gp) is a transmembrane protein that mediates the efflux of innumerous structurally unrelated compounds. It was initially found over-expressed in tumor cells, associated to a multidrug resistance phenotype (MDR). Then, P-gp was found constitutively expressed in excretory cells/tissues and in circulating cells, such as lymphocytes.(More)
The Human Immunodeficiency Virus can evolve to severe illness having a major impact on socio-demographic and economic features of the affected countries. Most countries rely on surveillance systems to monitor the status of the epidemic which are based on cases notification by physicians. It can take several months until the diagnosed cases are notified and(More)
OBJECTIVE The aim of this study was to identify dietary patterns in 13-y-old adolescents and to evaluate their association with socioeconomic and behavioral factors. METHODS Data from 1489 adolescents born in 1990 and enrolled in schools of Porto, Portugal, in 2003-2004 (EPITeen study) were analyzed, after excluding those without information on the food(More)
A new patient with factor VII Padua abnormality is presented. The proposita is an 11-year-old girl who showed a mild bleeding tendency and a laboratory pattern characterized by a prolonged prothrombin time corrected by normal serum, normal partial thromboplastin time and normal Thrombotest. Factor VII assay was 10% using rabbit brain thromboplastin and 100%(More)
Pharmaceuticals are continuously dispersed into the environment, as a result of human and veterinary use, and have become a relevant environmental concern. In the present study, the acute toxicity of three therapeutic agents (diazepam, clofibrate, and clofibric acid) and a detergent, sodium dodecylsulphate (SDS), to the euryhaline fish Gambusia holbrooki(More)
Emerging evidence suggests that hypertonic saline (HTS) is efficient in decreasing intracranial pressure (ICP). However there is no consensus about its interaction with brain hemodynamics and oxygenation. In this study, we investigated brain response to HTS bolus with multimodal monitoring after severe traumatic brain injury (TBI). We included 18(More)