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Native tissues are characterized by spatially organized three-dimensional (3D) microscaled units which functionally define cells-cells and cells-extracellular matrix interactions. The ability to engineer biomimetic constructs mimicking these 3D microarchitectures is subject to the control over cell distribution and organization. In the present study we(More)
The technological success of phase-change materials in the field of data storage and functional systems stems from their distinctive electronic and structural peculiarities on the nanoscale. Recently, superlattice structures have been demonstrated to dramatically improve the optical and electrical performances of these chalcogenide based phase-change(More)
While there has been significant progress in the treatment of ischemic heart failure, it remains a significant health and economic problem worldwide. In this paper, we present the challenges of modelling ischemic heart failure and introduce a user-friendly software system that will be a sub-set of the Virtual Pathological Heart environment which is(More)
A "multi-physics" numerical model that couples a detailed electrical description with the heat equation and with a microscopic picture of the phase transition dynamics is presented. This model, implemented in a three dimensional semiconductor device solver, correctly reproduces the electronic switching effect in the amorphous chalcogenide alloy and the(More)
Today phase change memory (PCM) technology has reached product maturity at 90 and 65 nm nodes, while the 45 nm node is under development and is expected to enter in the market soon. The continuous decrease of the cell size with scaling leads to an effective active area as small as 150 nm(2) and an active volume involved in the phase transformation of about(More)
This paper deals with the three-dimensional (3D) numerical simulation of the opening transient for a bileaflet mechanical heart valve (St. Jude Medical Hemodynamic Plus, 27 mm characteristic size). The discussion concerns two different types of ""partitioned"" fluid-structure models, with weak and strong coupling. Both approaches are based on a moving(More)
A multiphysics model for Phase Change Memory (PCM) is calibrated on a large set of experimental data. Critical material and interface properties such as electrical and thermal resistivities and their dependence on temperature are extracted from data or fitting electrical characteristics with numerical simulations. The model is shown to match with a unique(More)
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