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OBJECTIVE We used ultra-high field MRI to visualize cortical lesion types described by neuropathology in 16 patients with multiple sclerosis (MS) compared with 8 age-matched controls; to characterize the contrast properties of cortical lesions including T2*, T2, T1, and phase images; and to investigate the relationship between cortical lesion types and(More)
Cortical subpial demyelination is frequent in multiple sclerosis (MS) and is closely associated with disease progression and poor neurological outcome. Although cortical lesions have been difficult to detect using conventional MRI, preliminary data using T2*-weighted imaging at ultra-high field 7T MRI showed improved sensitivity for detecting and(More)
Introduction. In patients with multiple sclerosis, whether cortical lesions and cortical atrophy reflect two different aspects of the same degenerative process, or have different biological substrates, has not yet been clarified. It is unclear when cortical disease is a consequence of white matter (WM) demyelination with secondary axonal damage leading to(More)
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