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It is our conclusion that chronic cerebellar stimulation is both efficacious and safe as a therapeutic measure for selected neurological disease. Improvements in patient selection, with patients chosen who are not as incapacitated as those of our first group, showed make this even more apparent. In order to be certain that calibration of the present(More)
Two healthy females and twelve healthy males, aged 19-24 yr, underwent strength training for periods of 9-21 wk. The muscles trained included extensor digitorum brevis (N = 3), soleus (N = 7), brachioradialis (N = 4), and the hypothenar muscles (N = 3). The effect of training on motoneuron excitability was measured as the degree to which two reflex(More)
A review of the clinical results from 200 patients and the neurophysiological results from 42 patients suggests that chronic cerebellar stimulation (c.c.s.) can improve cerebral palsy and reduce intractable seizures. The therapeutic effects of stimulation of the cerebellar surface may not be due to activation of Purkinje cells. There is evidence that(More)
The objective was to assess the impact of transcranial magnetic stimulation (TMS) on pain and the autonomic nervous system (ANS) in migraine. Forty-two people [mean age 41.43+/-11.69 (SD) years, 36 females] were randomised into high vs. low TMS stimulation groups and received 2 brief pulses of TMS. Thirty-three (33/42) individuals had heart-rate variability(More)
BACKGROUND Stimulation of the left vagus nerve (VNS) has been shown to control seizures in double blinded crossover studies in man. Animal studies have reported vagal afferent induced depression of nociceptive and motor reflexes which may be caused by an effect on the descending reticular system controlling spinal cord function. Anticonvulsant drug therapy(More)
Six human subjects (5 male, 1 female, age 23.7 + 5.7 years) with incapacitating partial seizure disorders intractable to medical therapy have been treated by ongoing pulsed electrical stimulation of anterior nucleus of the thalamus. Four of the six patients have demonstrated statistically significant clinical control of the seizure disorder. One patient(More)
Stimulation of the thalamus and internal capsule with Medtronic deep brain stimulation electrodes produced improvement in pain, hemiparesis, dystonia, torticollis, tremor. speech impairment and epilepsy. Stimulation at voltages above or below clinically effective levels (e.g., 6 V, 0.3 ms, 74 Hz) resulted in a loss of clinical efficacy. Somatosensory evoked(More)
The power spectrum of heart rate variability contains low frequency (LF = 0.08-0.12 Hz) and high frequency (HF = 0.18-0.30 Hz) components said to represent neurocardiac rhythms. To verify whether such a relationship exists we report a unique study where the heart rate autospectrum was determined in a 28-year-old epileptic male patient with an implanted(More)
Motor disorders of disinhibition may be modified by prosthetic mobilization of CNS inhibitory mechanisms by chronic electrical stimulation of the cerebellar cortex (CCS) and by deep brain stimulation of the thalamus and internal capsule (DBS). Reduction in spasticity, abnormal movements, intractable epilepsy and aggressive behavior has been reported after(More)