A R D Stebbing

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Hormesis is the name given to the stimulatory effects caused by low levels of potentially toxic agents. When this phenomenon was first identified it was called the Arndt-Schulz Law or Hueppe's Rule because it was thought to occur generally. Although this generalisation is not accepted today, there has never been more evidence in its support, justifying a(More)
The wealth of examples of hormesis exhibiting the beta curve leave little doubt as to the generality of the phenomenon. However, its full acceptance requires a satisfactory theoretical basis to account for the diversity of instances of hormesis; without it the concept has little meaning beyond what is obvious from the defining beta curve. It has been(More)
A re-interpretation of the 'dose-response' curve is given that accommodates homeostasis. The outcome, or overall effect, of toxicity is the consequence of toxicity that is moderated by homeodynamic responses. Equilibrium is achieved by a balance of opposing forces of toxic inhibition countered by a stimulatory response. A graphical model is given consisting(More)
Data from experiments, in which colonies of a hydroid, Laomedea flexuosa, were exposed to a range of Cu2+ concentrations and a marine yeast, Rhodotorula rubra, was exposed to a range of Cd2+ concentrations, not only exhibit hormesis, but also suggest how its occurrence in growth experiments might be explained. When growth data are considered as normalized(More)
To date there is no single shared property of the various physical and chemical agents that elicit the beta-curve to account for its form, leading to the proposition that hormesis is a consequence of the nonspecificity of adaptive responses. It is argued that adaptive responses to toxic agents may be expected to follow the beta-curve. Four kinds of examples(More)
Cultured clones of the colonial hydroid Laomedeaflexuosa have been used over some years as an experimental model to study the dynamics of growth control [J. Mar. Biol. Ass. UK (1981a) 61, 35; Aquatic Toxicology (1981b) 1, 227; Journal of Applied Toxicology (2000a) 20, 93]. Exposure to toxic agents has been an essential element of the approach, providing the(More)
Data from experiments exposing colonial hydroids to toxic growth inhibitors have provided evidence of growth control mechanisms that respond adaptively to counter toxic inhibition. Analysis of growth data and the development of simulation models provide an interpretation of both alpha- and beta-curves. The hypothesis also suggests that hormesis is related(More)
  • A R Stebbing
  • Philosophical transactions of the Royal Society…
  • 1979
A case is presented for the use of experimental bioassay techniques to detect and measure variations in water quality in the marine environment by exposing suitable organisms in the laboratory to water samples collected in the field. A technique is described which was developed for this purpose with the use of a clonal hydroid; preliminary results from(More)
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