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  • John K. Lynch, Jennifer C. Freeman, +29 authors Philip R. Kym
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2006 (First Publication: 1 November 2006)
  • Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of aContinue Reading
  • James T. Limberis, Jeff McDermott, +6 authors Ruth Lee Martin
  • Chemistry, Medicine
  • Journal of pharmacological and toxicological…
  • 2007 (First Publication: 1 July 2007)
  • INTRODUCTION Drug-induced long QT syndrome (LQTS) has been linked to arrhythmias (including Torsades de Pointes and sudden cardiac death), and has led to an increased awareness of the potential riskContinue Reading
  • Andrew S. Judd, Andrew J. Souers, +24 authors Philip R. Kym
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Publication: 1 April 2007)
  • A series of potent 2-carboxychromone-based melanin-concentrating hormone receptor 1 (MCHr1) antagonists were synthesized and evaluated for hERG (human Ether-a-go-go Related Gene) channel affinity andContinue Reading