A Popov Mikhail
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Activators of the human ether-a-go-go-related gene (hERG) K(+) channel have been reported recently to enhance hERG current amplitude (five synthetic small molecules and one naturally occurring… Continue Reading
Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a… Continue Reading
INTRODUCTION Drug-induced long QT syndrome (LQTS) has been linked to arrhythmias (including Torsades de Pointes and sudden cardiac death), and has led to an increased awareness of the potential risk… Continue Reading
Delayed cardiac repolarization and fatal proarrhythmia have been linked to block of the repolarizing current, Ikr or hERG (human ether-a-go-go related gene) current. Thus, determining the potency of… Continue Reading
L'invention concerne des immunoglobulines qui se lient de maniere specifique a KV1.3, et plus particulierement des polypeptides, des acides nucleiques codant de tels polypeptides; des methodes de… Continue Reading
A series of potent 2-carboxychromone-based melanin-concentrating hormone receptor 1 (MCHr1) antagonists were synthesized and evaluated for hERG (human Ether-a-go-go Related Gene) channel affinity and… Continue Reading
Novel and specific activators of the human ether-a-go-go-related gene (hERG) K+ channel have been reported recently to enhance hERG current amplitude (4 synthetic small molecules and one naturally… Continue Reading
We have measured temperature and magnetic field dependences of the thermal conductivity along the c-axis, κc, and that along the  direction, κ110, of CuB2O4 single crystals in zero field and m...