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Unscheduled DNA synthesis refers to DNA synthesis not followed by cell division. Previous studies have suggested that this phenomenon may occur in neurons from peripheral myenteric ganglia in conditions of functional hyperstimulation. In order to verify these observations, we have carried on an immunohistochemical study on myenteric neurons from the(More)
We analysed using electrophoresis the total genomic DNA extracted from isolated Auerbach plexus ganglia of the hypertrophic duodenum upstream from a partial experimental stenosis. Results indicated the presence of two extra-bands migrating below the high molecular weight DNA. suggesting that DNA amplification is the basic mechanism of the DNA neosynthesis(More)
Some nerve cells of the Auerbach's myenteric plexus of the intestine of the adult rat, which hypertrophied following a surgically induced stenosis, began DNA synthesis unrelated to mitotic division. The cytophotometric analysis confirmed and quantified the amount of synthesis revealed by autoradiography with tritiated thymidine uptake. Numerous nerve cells(More)
A morphological analysis of types and sub-types of neurons from dorsal root ganglia at different spinal levels was carried out by combined light and electron microscopy in Podarcis sicula. Two neuron types were recognized: small dark cells (type D) and large light cells (type L). Type L cells were further sub-divided into three sub-types (L1, L2, L3) on the(More)
The variations occurring in neurons from dorsal root ganglia that provide innervation to the regenerated tail of the lizard (vicarious ganglia) are analysed. Vicarious ganglion neurons, when compared to control ganglion neurons (i.e. ganglia from the same animal that were not involved in the reinnervation process), show a size increase of the soma (cell(More)
In the present study, we conducted a morphometrical analysis of the different types and sub-types of lizard DRG neurons at various spinal levels. This analysis demonstrated significant differences in size distribution among the various neuron types and sub-types, as well as a significant shift to greater values in neurons from the dorsal root ganglia at the(More)
Calcium-binding proteins are present in different neuron populations in the Central Nervous System. As concerns the Enteric Nervous System, only a few studies have been performed. In the present work we investigated immunohistochemically the localization of Calretinin in neurons of the human intestinal wall. Our results showed the presence of stained cell(More)
Amputation of the lizard tail is followed by its complete regeneration over a period of six-eight months. The new tail is innervated only by the last three pairs of spinal nerves upstream from the plane of amputation, since no nerve cells are present in the regenerated. The corresponding dorsal root ganglia increase in volume (hypertrophic ganglia) and most(More)
Cytoplasmic and nuclear hypertrophy in neurons from the last 3 pairs of sensory ganglia left in situ cranially to the plane of amputation occurs during lizard tail regeneration. Cytophotometry after Feulgen staining demonstrated the presence of some neurons, from hypertrophic ganglia, whose quantity of DNA exceeded the diploid level (hyperdiploid neurons).(More)