A. P. Thompson

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Males, but not females, overproduce dopamine receptors in the striatum of rats across the periadolescent period followed by their elimination during young adulthood. In order to investigate the role that gonadal hormones play in this pubertal process, rats were castrated or ovariectomized at postnatal day (P) 28 when estrogen and testosterone levels are(More)
D(1) and D(2) receptors are overproduced and pruned in the mammalian striatum during the periadolescent period. The mechanism that underlies this process in striatum is unknown. However, previous research has shown that the activity-dependent pruning of dendrites and synapses in somatosensory cortex and the visual fields is mediated by glutamatergic actions(More)
The present study provides further evidence for transient D1 autoreceptor-like synthesis modulation in prefrontal cortex, but not striatum, of developing rats. DOPA accumulation was attenuated in a concentration-dependent manner in slices from the prefrontal cortex and striatum at 15 days of age by the partial D1 agonist SKF 38393 (0.01-10 microM) and the(More)
The stability of Wechsler Adult Intelligence Scale-Revised IQs was investigated for 52 students 16 years of age. Half of the subjects were retested after a 3-month interval; half after an 18-month interval. Stability coefficients were uniformly high for both retest intervals. Gains in Verbal, Performance, and Full Scale IQ over 3 months were similar to(More)
Scores on the Wechsler Adult Intelligence Scale-Revised (WAIS-R) and Wechsler Intelligence Scale for Children-Third Edition (WISC-III) were compared for 46 youth in the overlapping 16-yr.-age range. Students were administered the tests in a counterbalanced order with an average retest interval of 40 days. Self-reported grade average was also obtained from(More)
Molecular dynamics and other molecular simulation methods rely on a potential energy function, based only on the relative coordinates of the atomic nuclei. Such a function, called a force field, approximately represents the electronic structure interactions of a condensed matter system. Developing such approximate functions and fitting their parameters(More)
We develop a Genetic Programming-based [1] methodology that enables discovery of novel functional forms for classical inter-atomic fields, used in molecular dynamics simulations. Unlike previous efforts in the field, that fit only the parameters to the fixed functional forms, we instead use a novel algorithm to search the space of many possible functional(More)
This study investigated the similarity of Icelandic and English versions of the Basic Personality Inventory (BPI), a 240-item measure of psychopathology. Eighty-nine native Icelandic graduate students studying in North America completed both language versions of the BPI in a counterbalanced order with a retest interval of approximately one month. The(More)
The validity of a four-subtest short form (SF4) of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) was evaluated in a sample of incarcerated Caucasian and Native youth 16 to 18 years of age. A test-retest methodology was used in which 21 subjects received SF4 first and 26 subjects received the full WAIS-R first. Results showed that SF4 has validity(More)
The range of scaled scores does not provide information about the inaccuracy of estimates of IQ based on short forms of the test. Subtest scatter on a short form of an intelligence test may justify the complete administration for elaborative or clinical reasons. The criteria for reliable and abnormal ranges of scores for estimates based on short forms are(More)