A P Michler

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Modulation of neurite growth by gamma-aminobutyric acid (GABA) and several agonists and antagonists to its receptors was analysed in neuronal cultures of embryonic chick tectum and rat cerebellum, respectively, using morphometric methods. In each case, modulation of growth by GABA was similar in both types of neurons. However, data on neurite elongation(More)
The quality factor (Q), mode volume (V eff), and room-temperature lasing threshold of microdisk cavities with embedded quantum dots (QDs) are investigated. Finite element method simulations of standing wave modes within the microdisk reveal that V eff can be as small as 2(λ/n) 3 while maintaining radiation-limited Qs in excess of 10 5. Microdisks with a 2(More)
The effects of gamma-aminobutyric acid (GABA) and related agonists and antagonists on the excitatory cell death were examined in dispersed primary cultures of the rat cerebral cortex. The cytotoxic effects evoked by kainic acid, quisqualic acid and N-methyl-D-aspartic acid were evaluated by phase contrast microscopy and quantified by the measurement of(More)
Much recent effort has focused on coupling individual quantum emitters to optical microcavities in order to produce single photons on demand, enable single-photon optical switching, and implement functional nodes of a quantum network. Techniques to control the bandwidth and frequency of the outgoing single photons are of practical importance, allowing(More)
The excitotoxicity of glutamate, N-methyl-D-aspartate (NMDA), quisqualate and kainate were compared in rat cerebro-cortical cell cultures grown in different media. Excitotoxic cell death was examined by phase contrast microscopy and by the measurement of lactic dehydrogenase (LDH) activity released in the culture medium. Cells grown for 14 days in a(More)
The effects of gamma-aminobutyric acid (GABA) and selective agonists of GABAA and GABAB receptors were examined on excitotoxic cell death evoked in primary cultures of the rat cerebral cortex by glutamate and related excitotoxins. The activity of lactate dehydrogenase released from irreversibly damaged cells into the culture medium was taken as a measure of(More)
Experiments with dissociated chick dorsal root ganglion cells cultured in different media revealed the significance of non-neuronal cells for neurite growth along a physical boundary. The evidence presented suggests that fibrillary fibronectin deposited by non-neuronal cells guides neurites, rather than the physical boundary itself. This guidance is not a(More)
Neurite elongation was investigated in explanted chick dorsal root ganglia (DRG) using either serum-supplemented or defined N1 medium and different culture substrata. The results indicate that there is no substantial difference in neurite elongation on the three substrata when ganglia are grown in N1 medium. In contrast, neurite length depends on the(More)
In contrast to results of earlier investigations the influence of thyroxine on CNS connectivity is not restricted to circum-metamorphic stages in frogs. Neuroanatomical findings in adult Xenopus treated with thyroxine reveal a spread of the ipsilateral retino-tectal projection. Sprouting fibers establish a tectal innervation pattern similar to the one found(More)