A. P. Konijnenberg

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Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules. Defects in stress granule homeostasis constitute a cornerstone of ALS/FTLD pathogenesis. Polar residues (tyrosine and glutamine) have been previously demonstrated(More)
The multisubunit cullin RING E3 ubiquitin ligases (CRLs) target post-translationally modified substrates for ubiquitination and proteasomal degradation. The suppressors of cytokine signaling (SOCS) proteins play important roles in inflammatory processes, diabetes, and cancer and therefore represent attractive targets for therapeutic intervention. The SOCS(More)
Recently, efforts have been made to improve ptychography phase retrieval algorithms so that they are more robust against noise. Often the algorithm is adapted by changing the cost functional that needs to be minimized. In particular, it has been suggested that the cost functional should be obtained using a maximum-likelihood approach that takes the noise(More)
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