A. Ogiwara

Learn More
We have developed simulated annealing algorithms to solve the problem of multiple sequence alignment. The algorithm was shown to give the optimal solution as confirmed by the rigorous dynamic programming algorithm for three-sequence alignment. To overcome long execution times for simulated annealing, we utilized a parallel computer. A sequential algorithm,(More)
Recently we have constructed a database--the Enzyme-Reaction Database--which links a chemical structure to amino acid sequences of enzymes that recognize the chemical structure as their ligand. The total number of enzymes registered in the database is 1103 with 6668 NBRF-PIR entry codes and 1756 chemical compounds. The chemical structures and chemical names(More)
Gnome (GenomeNet Open Mail-service Environment) is a sequence analysis tool that enables an end-user to make use of several Internet- (mainly e-mail) based services with an easy-to-use graphical user interface. Users can conduct homology and motif searches, and database-entry retrieval against the latest databases by emitting search requests to and(More)
Although postoperative adjuvant chemotherapy (PAC) with uracil-tegafur significantly improves the prognosis of patients with stage I lung adenocarcinoma, subset analysis has revealed that only 11.5% of patients with stage IB derive actual benefit from such therapy. Therefore, it is extremely important to identify patients for whom adjuvant chemotherapy will(More)
The purpose of this study was to evaluate the association of antiphospholipid antibodies with the valvular lesions in patients with systemic lupus erythematosus (SLE). Two-dimensional and color Doppler echocardiographic studies were performed in 65 patients with SLE. Antiphospholipid antibodies were assayed in each patient using two methods: anticardiolipin(More)
Owing to an error on the part of the authors, mistakes were made in the assignment of protein names to the peptides found as biomarkers in the above paper. The last two graphs in Figure 1 entitled 'VIM_5' (lower middle) and 'VIM_6' (lower right) should be removed. They are not vimentin-derived peptide signals. The caption of Figure 1B should also be(More)