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  • Rachel E Sanborn, Michael J. Pishvain, +8 authors Tibor Keler
  • Medicine
  • 2016 (First Publication: 15 July 2016)
  • Preclinical studies have demonstrated synergistic antitumor activity when combining PD-1 blockade and varlilumab, a CD27 agonist antibody. The improved efficacy of the combination treatment wasContinue Reading
  • Scott J Rodig, Lecia V. Sequist, +5 authors Brian S. Schwartz
  • Medicine
  • 2012 (First Publication: 15 April 2012)
  • Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Background: A phase 2, randomized study of erlotinib administered with or without tivantinib, a selective c-METContinue Reading
  • Linda T. Vahdat, Andrés Forero-Torres, +16 authors Denise A. Yardley
  • Medicine
  • 2019 (First Publication: 15 February 2019)
  • Background gpNMB is an internalizable transmembrane protein overexpressed in ˜40% of TNBC, and associated with a worse prognosis. Preclinical data implicates gpNMB in tumor invasion and metastasis.Continue Reading
  • Georg F. Weber, Jeremy Warren, Hitoshi Shoma, Tao Chen, A O Abdel Halim, Geetika Chakravarty
  • Medicine
  • Cancer biology & therapy
  • 2012 (First Publication: 1 August 2012)
  • Biomarkers are biological agents used as indicators of biological states. In clinical applications, biomarkers reflect the presence, severity, or progression of disease states. They may also predictContinue Reading