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Exposing mice to 24 and 4 degrees C in alternate 1 hr periods in the day time and maintaining 4 degrees C at night for several days decreases the tail clamp pressure required to evoke pain behavior. This model is referred to as SART (specific alternation rhythm of temperature) stress. An extract from inflamed skin of rabbits inoculated with vaccinia virus(More)
We stated that SART-stressed guinea pigs showing nasal mucosal hypersensitivity would serve as an animal model for the in vivo evaluation of antiallergic drugs. In the present study, the mode of action of Neurotropin on nasal allergy compared with those of antiallergic drugs was studied by using SART-stressed guinea pigs. Daily administrations of(More)
Anesthetized rats were perfused with saline in the subcutaneous space of the hind paw and the release of inflammatory mediators induced by noxious stimuli was studied. Not only immunoreactive bradykinin (BK) but also histamine, serotonin (5-HT) and immunoreactive prostaglandin E2 (PGE2) were found to be released into the perfusate when the paw was pinched.(More)
In order to clarify to a greater extent its action on peripheral nerves, various experiments were conducted using denervated animals to determine the effects of the nervous sedative, Neurotropin (NSP, containing many types of polysaccharides), on the site considered to be the periphery of autonomic nerves and the central nervous system. The increase in(More)
In order to obtain evidences supporting the previous suggestion that restraint and water immersion stressed (RWIS) animals are possibly in the state of partial sympathicotonia, further investigations have been carried out. 1) In the experiment on the influence from the adrenal, the preadministration of dexamethasone, spironolactone or metopirone did not(More)
The contractile response to acetylcholine (ACh) of the isolated duodenum from the restraint and water immersion stressed (RWIS) mouse was found to be enhanced by the stress for 1 hr and reach a maximum in 3 hr stress followed by a decrease. It was clarified that this rise in the response is not due to the change in the affinity to ACh but due to the(More)
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