A. Nagasaka

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Gap junctions, formed by members of the connexin (Cx) family, are intercellular channels allowing direct exchange of signaling molecules. Gap junction-mediated intercellular communication (GJIC) is a widespread mechanism for homeostasis in organs. GJIC in the immune system is not yet fully understood. Although dendritic cells (DC) reportedly form(More)
Free radicals, hydroxyperoxides and H(2)O(2) are all known to damage cell components. This study was designed to compare the concentrations of hydroxyperoxide and free radical scavengers in the cardiac muscles of old rats in the hyper- or hypothyroid condition, to determine whether rates of peroxidation would differ with age, thyroid status, or both. Rats(More)
Endothelin-1 (ET-1) concentrations are increased in patients with diabetes mellitus, particularly those with diabetic retinopathy, or essential hypertension. We hypothesized that ET-1 might participate in the development and progression of diabetic microangiopathy. In this study, the effects of the angiotensin converting enzyme (ACE) inhibitor, enalapril(More)
Various definitions and models have been proposed to evaluate mental work load, for example, task time analysis method and secondary task method based on single channel model. However, an evaluating method utilizing physiological information has been comparatively newly proposed. Therefore, this method has not been adequately examined with respect to its(More)
It was only a several decades ago that physiological measurements were recognized as effective indicators of human physical and mental conditions in occupational health or ergonomics. The recent rapid progress in sensor and signal processing techniques, however, made these available for practical evaluation techniques. This paper is an overview of the(More)
The effects of somatostatin and dopaminergic agents on pituitary cyclic nucleotide phosphodiesterases that had been partially purified through DEAE cellulose column chromatography were studied. Somatostatin, L-dopa, dopamine and CB-154(2-bromo-alpha-ergocriptine) competitively inhibited the pituitary cyclic AMP phosphodiesterase activity, especially that of(More)
To estimate cavity availability for species with diverse cavity requirements, we recorded cavities in eight deciduous hardwood forests in Hokkaido, Japan, and classified them into two categories based on their entrance width (small, 2.5–5 cm; large, ≥5 cm). In two of the forests, we inspected cavity interiors and classified cavities into three further(More)
It is important in establishing and improving work management and work planning to estimate the arousal level of workers during operation and monitoring tasks. This paper proposes a technique based on experimental results to estimate the arousal level during job execution. In this experiment, both a monotonous low workload task which degrades the arousal(More)
Thyroid hormones effectively inhibited partially purified cyclic AMP phosphodiesterase from the anterior and posterior lobes of bovine pituitary gland competitively with the substrate, but thyronine, diiodotyrosine, monoiodotyrosine, thyrotropin, thyrotropin releasing hormone, dexamethasone, and luteinizing hormone releasing hormone did not inhibit this(More)
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