A N Verkhratskiĭ

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Block of sodium currents by allapinine (diterpene alkaloid with strong antiarrhythmic properties) was investigated in isolated, voltage-clamped trigeminal neurons of a rat and single ventricular myocytes of a neonatal rat. Allapinine (in micromolar concentrations) produced a 70-90% decrease of the sodium current amplitude without any changes in(More)
The effect of a drop of extracellular pH on the fast and slow sodium currents (INaf and INas) was studied in the rat isolated perfused ventricular myocytes. The shift of the extracellular pH value from 7.4 to 5.0 caused a disappearance of INaf. If the fast sodium current was blocked by external tetrodotoxin (10(-6) mol/l) or inactivated by the shift of the(More)
Dual wavelength microfluorometry was used to measure the cytoplasmic free calcium concentration [( Ca2+]in) in single cultured cells from ventricular myocytes of neonatal rats loaded with the indicator fura-2. At 2.5 nmol/l extracellular Ca2+ in the resting cells [Ca2+]in was between 80 and 110 nmol/l. Sometimes, spontaneous low-frequency (approximately 0.1(More)
Thin cardiac slices (100-200 microns) from newborn (1-14 days old) rat heart ventricles were used for patch clamp recordings. High resistance seals (10-50 GOhms) between patch-clamp pipettes and the membrane of cardiac cells as well as classical patch-clamp configurations can be achieved on this preparation without any enzymatic treatment of tissue.(More)
In isolated, cultured neonatal rat ventricular myocytes calcium current was investigated by whole-cell patch clamp technique. The shift of holding potential values from -100-80 mV to -40 mV caused no significant changes in calcium current potential-dependent and kinetic properties. No calcium current component with preferential steady-state inactivation at(More)
Block of sodium currents by allapinin (diterpene alkaloid with strong antiarrhythmic properties) was investigated in isolated, voltage clamped rat trigeminal neurons and cultured neonatal rat single ventricular myocytes. Allapinin produces a decrease in sodium current amplitude without any changes in voltage dependent properties. Possible differences(More)