A. N. Murashov

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Atherosclerotic plaque formation and vascular calcinosis were modeled in a subchronic experiment. Reduced HDL and elevated LDL concentrations, increased atherogenic index and albumin toxicity index, and high blood levels of triglycerides and uric acid were early markers of pathology. Xydiphone in combination with vitamin D effectively reduced these changes(More)
Reaction of a high-temperature solid-phase catalytic isotope exchange in peptides and proteins under the action of the catalytically activated spillover hydrogen was studied. The reaction of human recombinant insulin with deuterium and tritium at 120–140°C resulted in an incorporation of 2–6 isotope hydrogen atoms per one insulin molecule. The distribution(More)
The effect of daflon administration (100 mg/kg/day, p.o., over 8 days) upon the transcapillary fluid shift in the hind extremities of narcotized rats was studied. The effect was evaluated by the arterio-venous difference of the blood density (orthostatic versus antiorthostatic). The treatment reduced the level of fluid filtration from the vascular channel(More)
The reaction of high temperature solid state catalytic isotope exchange in peptides and proteins under the action of catalyst-activated spillover hydrogen was studied. The reaction of human gene-engineered insulin with deuterium and tritium was conducted at 120-140° C to produce insulin samples containing 2-6 hydrogen isotope atoms. To determine the(More)
An experimental model was developed for the study of antiedemic drug activity in anesthetized rats. The effect of furosemide upon the transcapillary fluid shift was studied. It is shown that the character of changes in the arterio-venous difference of blood density in response to postural (orthostatic versus antiorthostatic) changes can be used to udge on(More)
The administration of moxonidine for two weeks in a daily dose of 2 or 10 mg/kg (p.o.) reduced the cardiac sympathetic tone in stroke-prone spontaneously hypertensive rats (SHR-SP) by 24.3 +/- 7.3 and 32.2 +/- 10.2%, respectively. In addition, the treatment influenced the cardiac baroreflex by decreasing the bradycardic plateau and increasing both(More)
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