A N Iavorskiĭ

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Experiments were conducted on male rats; by means of quantitative cytochemical analysis and karyometry circadian rhythm of the hypothalamo-hypophysial neurosecretory system function was studied. In the evening (9--10 p.m.) the intensity of the synthesis, transport, and neurosecretion showed a significant elevation in comparison with the day (3--4 p.m.).(More)
Experiments on 200 noninbred male rats have demonstrated that daily administration of ethanol per os in a dose of 8 g/kg (2/3 LD50) for a month produced pathological changes in organs and systems of the body, which were similar to the manifestations of chronic alcoholic intoxication in man. It is concluded that the model under consideration may be used(More)
It has been shown in experimental chronic intoxication that there is a close correlation between the dose of ethanol, microscopic appearance of the liver, the content of DNA, RNA, protein, glycogen in hepatocytes and structural parameters of nuclear chromatin of these cells. It is concluded that automatic cytophotometric analysis of the structure of(More)
The direct and indirect effects of cefuroxime on the embryo and fetus were studied in vitro and in vivo at different gestation times. The placenta, liver and kidneys of the mother and fetus were investigated morphologically. It was shown that in a dose of 250 mg/kg the antibiotic did not induce disorders in the fetus development. The histological(More)
It has been shown in acute experiments on rats, rabbits and cats that under extracorporeal pulmonary ventilation, the animals could tolerate the 50-100 fold apnoeic doses of diadonium. Chronic experiments have demonstrated that administration of the subapnoeic doses of diadonium to rats, rabbits, and dogs and the apnoeic doses to rats (under extracorporeal(More)
The rat experiments studied the impact of inductors and inhibitors of enzymatic activity of xenobiotic metabolism on the pharmacological activity of sodium thiopental and ketamine and on the pharmacokinetics of sodium thiopental. Cocarboxylase, cobalt chloride and cimetidine enhanced the pharmacological action of sodium thiopental, but failed to exert any(More)
Study of toxicological characteristic of teturam (200 mg/kg, administered into the stomach through a tube daily for 2 weeks) on the model of alcoholic intoxication in rats (ethanol, 8 g/kg, administered into the stomach through a tube daily for 1 month) confirmed the literature data on the drug's ability to enhance or maintain ethanol-induced pathological(More)
Administration of ethanol in a dose of 4 g/kg (1/3 of the LD50) from the 1st to the 14th day after partial hepatectomy retards the reparative regeneration of the rat liver. At the cell level this effect is realized at the expense of the reduced cell division followed by mitosis replacement by intracellular pattern of regeneration as hypertrophy and(More)
The morphological appearance and morphometric indicators (the content of RNA, protein, glycogen and fat) of the internal organs of random-bred male rats were studied 10 days, 6 and 12 months after voluntary consumption of 15% ethanol. Alcohol consumption for 12 months provoked marked pathological alterations of the animals' internal organs, similar to organ(More)
A selective uptake of ethanol by presenting its 5% solution as the only source of fluid was elaborated in rats for 2 months. It was found that lithium chloride injected intravenously in a dose of 35 mg/kg twice per 24 hours for 14 days depressed the ethanol preference causing a motivation inversion whose mechanism was associated with the changes in the(More)