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Journals and Conferences
New derivatives of betulin, betulinic acid methyl ester, and their acetate analogs containing 1,2,3-triazole fragments in the C-30 position were synthesized. It was shown using the Ames test that 30-azidolup-20(29)-enes and 3β,28-diacetoxy-30-(4-R-1,2,3-triazol-1-yl)lup-20(29)-enes did not exhibit mutagenic properties.
19-(2,6-Dimethylpyrid-4-yl)-20,29,30-trinorlupanes in addition to triterpenoid derivatives condensed in ring A of the pyran-4-one ring were synthesized for the first time from betulin, betulin diacetate, and methyl esters of 3-acetylbetulinic and betulonic acids.
Interaction of betulonic acid chloride with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl, and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl yielded the corresponding triterpene amides. The synthesized derivatives of betulonic acid were shown to exhibit a cytotoxic activity on models of the CEM-13, U-937,… (More)
Betulonic acid amides containing the nitroxyl radical moiety exert an anticholestatic effect in mice. The introduction of piperidine nitroxide moiety into the lupane core increases its hepatoprotective activity. Oral administration of the piperidine nitroxide derivative in a dose of 50 mg/kg does not stimulate transplanted tumor growth and increases… (More)
The reaction of betulonic acid chloride with 4-amino-2,2,6,6-tetramethylpeperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl gave corresponding triterpenoid amides. It was found that new derivatives exhibit cytotoxic activity against tumor cells CEM-13, U-937, MT-4. CCID50 value for most… (More)
Betulonic acid amides of interest as potential biologically active compounds were prepared.
New derivatives of betulonic and betulinic acids with 1,3,4-oxadiazole substituents in the C-17 position were prepared. The cytotoxic activity of the betulonic acid derivatives was studied using MT-4, CEM-13, and U-937 human tumor cell models.