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INTRODUCTION The use of the 5-alpha reductase inhibitors (5-ARIs) finasteride and dutasteride for prostate cancer prevention is still under debate. The FDA recently concluded that the increased prevalence of high-grade tumors among 5-ARI-treated patients must not be neglected, and they decided to disallow the use of 5-ARIs for prostate cancer prevention.(More)
consideration that MMPs may help in the bioavailability of these growth factors for tissue restoration, the enhancement of MMPs' activity triggered by Fn accumulation may further influence the outcome of tissular regeneration, reinforcing an extra role of Fn in this process. In a later section of the paper, the authors state that, in the case of impaired(More)
BACKGROUND The prevalence of chronic venous disease is high and occurs more frequently in females. According to the clinical, etiological, anatomical, and pathological classification (CEAP) definition, the reticular veins are included in the C1 class and are mainly associated with aesthetic complaints. Several invasive techniques are used for treatment,(More)
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