A. Molero

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Adenosine A(2A) (A(2A)R) and dopamine D(2) (D(2)R) receptors mediate the antagonism between adenosinergic and dopaminergic transmission in striatopallidal GABAergic neurons and are pharmacological targets for the treatment of Parkinson's disease. Here, a family of heterobivalent ligands containing a D(2)R agonist and an A(2A)R antagonist linked through a(More)
Ligands acting at multiple dopamine receptors hold potential as therapeutic agents for a number of neurodegenerative disorders. Specifically, compounds able to bind at D1R and D2R with high affinity could restore the effects of dopamine depletion and enhance motor activation on degenerated nigrostriatal dopaminergic systems. We have directed our research(More)
— This paper describes the implementation of a model predictive controller novel in an underwater robot vehicle. This work also shows the development of an underwater vehicle model that accounts for physical, hydrodynamic and restorative effects, while the damping coefficients are neglected in the prediction of the vehicle position and orientation. The(More)
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