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Homozygosity for lethal(2)giant larvae (lgl), a mutation in a tumor suppressor gene of Drosophila, induces neoplasia of the imaginal discs. To explore the developmental capacities of lgl mutant cells, we have investigated their growth and differentiation in genetic mosaics. Adult wings mosaic for lgl displayed abnormal growth and differentiation of the lgl(More)
A recessive semi-lethal mutation resulting from the insertion of a P-lacW transposon at the cytological position 23A on the polytene chromosomes of Drosophila melanogaster was found to affect the unfolding and expansion of the wings resulting in a loss of venation and a marked decrease in their size. Lethality was polyphasic with numerous animals dying(More)
BACKGROUND To investigate foot pressure distribution parameter-power ratio (PR) difference between pre-obese and non-obese adults subjects during standing and show the correlation between body mass index (BMI) and PR value. METHODS We examined 22 healthy adult subjects aged from 20 to 45 years were classified into two groups according to their BMI values,(More)
Abstact: Saraca indica is popularly known as Ashoka and one of the most legendary and sacred trees of India. Saraca indica is a medicinal plant widely used in Ayurveda to treat painful conditions, improves complexion of the body, improves digestion and assimilation, alleviates excessive thirst, to kills all infectious agents, in blood disease, inflammation(More)
OBJECTIVES To study the prevalence of beta-thalassemia mutations in two North Indian states. DESIGN AND METHODS Mutation(s) were analyzed in 62 patients using 10 sets of allele-specific primers. RESULTS Four mutations [IVS1 nt5 (G --> C), F.S 8/9 (+G), F.S 41/42 (-TCTT) and del 619 bp] were found to constitute 94.1% of the total alleles studied.(More)
A theoretical study of possible neuromuscular incapacitation based on the application of high-intensity, ultrashort electric pulses is presented. The analysis is applied to a rat, but the approach is general and can be extended to any whole-animal and applies for any arbitrary pulse waveform. It is hypothesized that repeatable and reversible action(More)
Lethal mutations in the giant discs (lgd) and fat (ft) tumor suppressor genes of Drosophila cause epithelial hyperplasia in all imaginal discs. By contrast, mutations in the vestigial (vg) gene adversely affect cell viability in the wing imaginal discs and consequently cause loss of pattern in the adult wings. However, combining homozygous lgd or ft(More)
The canonical Wnt cascade has emerged as a critical regulator of cancer cells. Activation of the Wnt signaling pathway has also been associated with stem cell, thus raising the possibility of its role in embryogenesis and in the proliferation of malignant cancer cells. Wnt pathway has been reported to be involved in normal physiological processes in adult(More)