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BACKGROUND Uridine adenosine tetraphosphate (Up4A) was been recently characterized as a potent vasoconstrictor. Up4A occurs in plasma from healthy subjects at concentrations sufficient to cause strong vasoconstrictive effects. In this study, Up4A concentrations in plasma from juvenile hypertensives and normotensives were determined. METHODS AND RESULTS(More)
Abstract Aims/hypothesis. The concentration of asymmetrical dimethyl-L-arginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, is increased in patients at risk or with cardiovascular disease. We have investigated ADMA concentrations in women with a history of gestational diabetes (GDM), who could develop endothelial dysfunction and Type II(More)
The persistent effect of doramectin injectable against gastrointestinal nematodes was investigated in a controlled field study with 70 sheep kept on alpine pastures in Switzerland. After grazing on home pastures for four weeks 50 lambs and 20 ewes were allocated to two equal groups according to age and body weight. At turnout to alpine pasture in June(More)
Metastasis of an adenocarcinoma was diagnosed histologically in a foot pad biopsy of a cat exhibiting progressive locomotion problems, foot pad swelling and nail loosing. A bronchial gland adenocarcinoma was identified as primary tumour at necropsy. Metastases were found in all foot pads, the kidneys and various lymph nodes. A review of the literature and(More)
AIM The aim of this study was to investigate the effect of long-term treatment with the dipeptidyl peptidase inhibitor P32/98 and its combination with rosiglitazone on blood glucose control and islet of Langerhans histology in male Zucker diabetic fatty (ZDF) rats, when treatment begins before or after the development of overt diabetes. METHODS ZDF rats(More)
Based on three cases of foetal abnormalities (hydrocephalus, prune-belly syndrome, and unilateral multicystic renal disease) diagnosed and treated by intrauterine sonographic control, the article describes the technique, evolution and outcome of these cases. Two patients (the hydrocephalus and the prune-belly syndrome) died after delivery, whereas the third(More)