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Most cellular processes are carried out by multiprotein complexes. The identification and analysis of their components provides insight into how the ensemble of expressed proteins (proteome) is organized into functional units. We used tandem-affinity purification (TAP) and mass spectrometry in a large-scale approach to characterize multiprotein complexes in(More)
Reliable and timely fault detection and isolation are necessary tasks to guarantee continuous performance in complex industrial systems, avoiding failure propagation in the system and helping to minimize downtime. Model-based diagnosis fulfils those requirements, and has the additional advantage of using reusable models. However, reusing existing complex(More)
Reaching as high structural resolution as possible in 3D electron microscopy of biological specimens is crucial to understanding their function and interactions. Technical and biological limitations make electron microscopy projections of such specimens quite noisy. Under those circumstances, the broadly used Weighted Back-Projection algorithm presents some(More)
Echinomycin, a member of the quinoxaline family of antibiotics, is known to be a small-molecule inhibitor of hypoxia inducible factor-1 (HIF-1) DNA binding activity. Recently, it has been shown to suppress mammalian target of rapamycin (mTOR) signaling and growth in leukemia cell lines. In this study, we investigated whether echinomycin interacts with the(More)
This paper shows the application of a 2DOF robust discrete deadtime compensator to a evaporation process in a sugar factory. The proposed controller is tuned using performance and robustness specifications and it is specially designed for integrative plants as is the case of the level control of the principal unit of the evaporator. A comparative analysis(More)
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