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We have compared the effect of increasing optode separation (range 0.7-5.5 cm) on the sensitivity of near infrared spectroscopy (NIRS) to discrete reductions in scalp and cerebral oxygenation in 10 healthy men (mean age 32, range 26-39 yr) using multichannel NIRS. During cerebral oligaemia (a mean reduction in middle cerebral artery flow velocity of 47%)(More)
OBJECTIVE To determine the prognostic value of multimodal evoked potentials (EPs) and event-related (ERPs) potentials in coma (Glasgow Coma Score <8), after severe traumatic brain injury (TBI). DESIGN Prospective, longitudinal study of neurophysiological responses recorded during traumatic coma. SETTING Intensive Care Unit, Frenchay Hospital, Bristol,(More)
BACKGROUND Studies on the effects of anaesthesia on event-related potentials and long latency auditory-evoked potentials (AEP) are sparse. Both provide information on cortical processing and may have potential as monitors of awareness. We studied the effect of propofol on the event-related potential mismatch negativity (MMN) and the long-latency AEP NI. (More)
We have previously shown that eating disorders are a compulsive behaviour disease, characterized by frequent recall of anorexic thoughts. Evidence suggests that memory is a neocortical neuronal network, excitation of which involves the hippocampus, with recall occurring by re-excitement of the same specific network. Excitement of the hippocampus by(More)
The detection of increased cerebral oxygenation secondary to cerebral hyperaemia, induced by hypercapnia has been studied in anaesthetised patients using a near infrared, reflectance mode, cerebral oxygenation monitor (Invos 3100 Somanetics, Troy, Michigan, USA). Two studies were performed, with and without a pneumatic scalp tourniquet, to distinguish(More)
This systematic review delineates the effect of primary therapeutic hypothermia (PTH) (initiated on presentation of the patient) on both mortality and neurological outcome in patients with traumatic brain injury. The safety profile of the therapy is also assessed. A systematic search of the following databases was performed: MEDLINE, EMBASE, Zetoc database(More)
Editor's key points † Death can be diagnosed using three different sets of criteria: circulatory, somatic, and neurological. † These criteria are now robust, specific, and based on scientific principles. † A diagnosis of death requires irreversible loss of the capacity for consciousness and capacity to breathe. † Additional minimum observation periods are(More)
The International Telecommunication Union (ITU) Regional Radio Conference (RRC06) established in 2006 a new frequency plan for the introduction of digital of the plan involved complex calculations under short deadline and required dependable and ecient computing capability. The ITU designed and deployed in-situ a dedicated PC farm, in parallel to the(More)
The ABC1K family of atypical kinases (activity of bc1 complex kinase) is represented in bacteria, archaea, and eukaryotes. In plants they regulate diverse physiological processes in the chloroplasts and mitochondria, but their precise functions are poorly defined. ABC1K7 and ABC1K8 are probably involved in oxidative stress responses, isoprenyl lipid(More)
Human industry, farming, and waste disposal practices have resulted in the large-scale contamination of soil and water with organic compounds and heavy metals, with detrimental effects on ecosystems and human health. Conventional soil remediation methods are expensive and often involve the storage of soil in designated areas, postponing rather than solving(More)