A. Maier

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In this paper, we present the computational task-management tool Ganga, which allows for the specification, submission, bookkeeping and post-processing of computational tasks on a wide set of distributed resources. Ganga has been developed to solve a problem increasingly common in scientific projects, which is that researchers must regularly switch between(More)
The uncertainty factor concept is integrated into health risk assessments for all aspects of public health practice, including by most organizations that derive occupational exposure limits. The use of uncertainty factors is predicated on the assumption that a sufficient reduction in exposure from those at the boundary for the onset of adverse effects will(More)
The fundamental goal of this article is to describe, define, and analyze the components of the risk characterization process for occupational exposures. Current methods are described for the probabilistic characterization of exposure, including newer techniques that have increasing applications for assessing data from occupational exposure scenarios. In(More)
Occupational exposure limits (OELs) serve as health-based benchmarks against which measured or estimated workplace exposures can be compared. In the years since the introduction of OELs to public health practice, both developed and developing countries have established processes for deriving, setting, and using OELs to protect workers exposed to hazardous(More)
Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach for the rapid identification of DNA(More)
Lung cancer caused by polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and related environmental agents is a major problem in industrialized nations. The high case-fatality rate of the disease, even with the best supportive treatment, underscores the importance of primary lung cancer prevention. Development of biomarkers of exposure and effects to PAHs(More)
Occupational exposure limits (OELs) serve as benchmarks for the interpretation of workplace exposures within a health risk context. Different organizations derive OELs for many chemicals, including manganese. OELs recommended by different organizations can vary quantitatively, which can present a challenge to occupational hygienists or other risk managers(More)
Occupational exposure limits have traditionally focused on preventing morbidity and mortality arising from inhalation exposures to individual chemical stressors in the workplace. While central to occupational risk assessment, occupational exposure limits have limited application as a refined disease prevention tool because they do not account for all of the(More)
  • Johannes Elmsheuser, Frederic Brochu, Ivan Dzhunov, Johannes Ebke, Ulrik Egede, Manoj Kumar Jha +11 others
  • 2011
Ganga is a grid job submission and management system widely used in the ATLAS and LHCb experiments and several other communities in the context of the EGEE project. The particle physics communities have entered the LHC operation era which brings new challenges for user data analysis: a strong growth in the number of users and jobs is already noticeable.(More)