A. M. Silverstein

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An animal model of chronic cicatrizing trachoma has been produced by repeated ocular inoculation with Chlamydia trachomatis serotype E, a genitally transmitted strain. We have now produced a chronic follicular conjunctivitis on cynomolgus monkeys by repeated inoculation with C. trachomatis serotype A, which has been isolated from an area of endemic(More)
The fetal lamb was found to reject orthotopic skin homografts applied at any time after the 77th day of gestation. Prior to this, grafts remained in place without stimulating any detectable immunologic response. Once the fetus achieves the ability to reject the graft, the process occurs with the same competence and rapidity as in the adult. Graft rejection(More)
Further data have been presented showing that the specificity of the delayed hypersensitivity reaction in the guinea pig to hapten-protein conjugates involves to a considerable degree a contribution by the protein carrier. The carrier contribution is such that sensitization to guinea pig albumin-m-azobenzenesulfonate, for example, does not result in(More)
The cross-reactions of conjugates carrying structurally related haptens have been studied in guinea pigs with delayed sensitivity to hapten-protein conjugates. The specificity of the delayed reaction has been found to be a function both of the nature and of the position of the substituent on the benzene ring; the cross-reactions shown in the delayed system,(More)
Although the fetal lamb is unable to form circulating antiovalbumin antibodies until about 120 days of gestation, ovalbumin-specific helper T cells can be stimulated to function at an earlier age. This would suggest that the critical event responsible for the precise sequential maturation of immunologic competence to different antigens at different(More)
I have attempted here to define three distinct eras in the 110-year history of the discipline of immunology. The first, extending from 1880 to about the First World War, centered around the new bacteriology and infectious diseases, and had a distinctly medical orientation. Several of the components of the original research program in immunology failed to(More)