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A prominent feature of the hepatic response to injury is production of a fetal isoform of fibronectin, a splice variant containing the EIIIA region, which appears very early after injury and derives from sinusoidal endothelial cells. Previous studies have shown that it is instrumental in initiating the cellular response to injury, specifically the(More)
in Spanish (author: Graciela Diap) Cien años desde el descubrimiento de la enfermedad de Chagas (CD), se ha avanzado en el tratamiento de esta enfermedad que amenaza a una cuarta parte de la población que vive en América Latina con una mayor atención recientemente otorgada a esta enfermedad olvidada, iniciativas como el INCOSUR-Chagas “Iniciativa del Cono(More)
At a recent meeting (Sept 18, 2009) in which reasons for the limited access to artemisinin-based combination therapy (ACT) in sub-Saharan Africa were discussed, policy and market surveys on anti-malarial drug availability and accessibility in Burundi and Sierra Leone were presented in a highly interactive brainstorming session among key stakeholders across(More)
Transforming growth factor beta (TGF-beta) is an antiproliferative and profibrogenic cytokine that signals through a receptor consisting of type I and type II (TbetaRII) components. We have examined changes in the expression of TbetaRII during liver injury, correlating this with the antiproliferative and profibrogenic effects of TGF-beta1. The experimental(More)
Abdul Moiz Khan The problems of the overwhelming amount of medical literature have been thoughtfully highlighted in the PLoS Medicine editorial “Drowning or Thirsting: The Extremes of Availability of Medical Information” [1]. It is of vital importance to medical professionals that they improve on their skills of sifting through the huge amounts of(More)
Endemic throughout Latin America with a prevalence rate of approximately 1.4%, Chagas disease (CD) is estimated to kill 14,000 people every year, which is more people in the region each year than any other parasite-born disease, including malaria [1,2]. Brazilian physician Carlos Chagas first described CD exactly a century ago [3], and its socioeconomic(More)
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