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OBJECTIVES To survey the frequency of use of indirect comparisons in systematic reviews and evaluate the methods used in their analysis and interpretation. Also to identify alternative statistical approaches for the analysis of indirect comparisons, to assess the properties of different statistical methods used for performing indirect comparisons and to(More)
BACKGROUND Although the second half of the last century has generated a rich and complex body of knowledge, the burden of oral cancer is still largely present. As with other cancers, there has been a strong debate whether screening strategies for oral cancer such as visual examination, the use of toluidine blue or newer methods such as brush biopsy or(More)
OBJECTIVE To determine the effectiveness of interventions designed to prevent and treat obesity, and maintain weight loss. DESIGN A systematic review of randomised controlled trials. SUBJECTS Overweight and obese adults and children. MEASUREMENTS Post-intervention changes in weight, fat content and fat distribution, measured relative to baseline. (More)
Objective: To evaluate published reviews of the appropriateness of prophylactic removal of impacted third molars.Design: Systematic review and critical appraisal of relevant reviews.Methods: Computerised databases (Medline and Embase), the Index to Dental Literature, and the references of articles were searched to identify relevant reviews.Main Outcome(More)
BACKGROUND Dentine hypersensitivity may be defined as the pain arising from exposed dentine, typically in response to external stimuli, and which cannot be explained by any other form of dental disease. Many treatment regimens have been recommended over the years, and in recent years particular attention has been focused on toothpastes containing various(More)
This article summarises the findings of a systematic review of the literature concerning antimicrobial prophylaxis before colorectal surgery. From analysing 152 clinical trials certain conclusions can be drawn, such as the importance of ensuring that prophylactic therapy is active against both aerobic and anaerobic bacteria; and, single dose treatment can(More)
OBJECTIVES To conduct a systematic review of epidemiological literature in order to determine the prevalence and associated risk factors of oro-facial pain. DATA Population based observational studies (cohorts, cross-sectional and case-control studies) of oro-facial pain, published in the English language, prior to 1999 were included. SOURCES Electronic(More)