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Intelligent Agents are being used for modelling simple rational behaviours in a wide range of distributed applications. In particular, multi-agent architectures based on the Belief-Desire-Intention model have been used successfully in situations where modelling of human reasoning and team behaviour are needed, such as simulating tactical decision-making in(More)
Idiosyncratic adverse drug reactions are unpredictable, dose-independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkages between drug(More)
Air combat modelling using graphical simulation is a powerful means for development and evaluation of tactics. However, large models are particularly expensive and time-consuming to maintain and modify. Multi-aircraft full mission man-in-the-loop simulators will provide an even more complex programming environment. Agent-oriented architecture provides a(More)
The introduction of highly active antiretroviral therapy (also known as combination therapy) has transformed the nature of HIV infection from a severe and ultimately fatal disease to that of a manageable chronic condition. HIV drugs are highly efficacious, but their use comes at the cost of a range of drug-related adverse events, including severe drug(More)
BACKGROUND Diagnosis of latent tuberculosis infection (LTBI) is a cornerstone of the health assessment of resettled high incidence populations, particularly in children. Two blood-based interferon gamma release assays (IGRAs), T-SPOT.TB and QFT-Gold in-tube (QFT-GIT), have greater sensitivity and specificity than the tuberculin skin test (TST), but their(More)
BACKGROUND Abacavir hypersensitivity in genetically susceptible individuals implicates an abacavir-specific T-cell response to either the parent drug or a metabolite generated in vivo. We have analysed the cytokine profile in antigen-presenting cells and the T-lymphocytes that are involved in the pathological immune response to abacavir. METHODS In this(More)
This paper describes research into automated support for air traac controllers performing tactical air traac management. It describes the OASIS system developed to help alleviate air traac congestion. The system achieves this by maximizing runway utilization, achieved through arranging landing aircraft into an optimal order, assigning them a landing time,(More)
The enzyme linked immunospot (ELISpot) assay is a fundamental tool in cellular immunology, providing both quantitative and qualitative information on cellular cytokine responses to defined antigens. It enables the comprehensive screening of patient derived peripheral blood mononuclear cells to reveal the antigenic restriction of T-cell responses and is an(More)
Environmental changes affecting the relationship between the developing immune system and microbial exposure have been implicated in the epidemic rise of allergic disease in developed countries. While early developmental differences in T cell function are well-recognised, there is now emerging evidence that this is related to developmental differences in(More)
We reported previously that a proportion of natural CD25(+) cells isolated from the PBMC of HCV patients can further upregulate CD25 expression in response to HCV peptide stimulation in vitro, and proposed that virus-specific regulatory T cells (Treg) were primed and expanded during the disease. Here we describe epigenetic analysis of the FOXP3 locus in(More)