A. L. Darling

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Auditory filters broaden with increasing level. Using a recently developed method of fitting filter shapes to notched-noise masking data that explicitly models the nonlinear changes in filter shape across level, results at 2 kHz from 9 listeners over a wide range of levels and notch widths are reported. Families of roex(p,w,t) filter shapes lead to models(More)
One of the dominant approaches to tissue engineering is the seeding of biodegradable, biocompatible polymer scaffolds with progenitor cells prior to 3D culture or implantation. The microarchitecture of these scaffolds has direct effects upon the ability of cells to attach, migrate, and differentiate. Microtomographic (micro-CT) scanners enable high-speed 3D(More)
One of the dominant approaches to tissue engineering is the seeding of biodegradable, biocompatible polymer scaffolds with progenitor cells prior to three-dimensional (3-D) culture or implantation. While the macroarchitecture of these scaffolds is important for anatomic fit, the microarchitecture has direct effects upon the ability of cells to attach,(More)
One of the dominant approaches to tissue engineering is the seeding of biodegradable, biocompatible polymer scaffolds with progenitor cells prior to 3D culture or implantation. The microarchitecture of these scaffolds has direct effects upon the ability of cells to attach, migrate, and differentiate. Microtomographic (micro-CT) scanners enable high-speed 3D(More)
The dominant approach in 3D tissue engineering is to construct a scaffold of biocompatible material, to seed the scaffold with an appropriate cell type, to culture these cells in a bioreactor, and to implant the resulting tissue construct. Numerous individual materials have been investigated, but no single material has proven ideal for tissue culture. We(More)
Precision extruding deposition (PED) process was used to directly fabricate Polycaprolactone (PCL)/hydroxyapatite (HA) composite tissue scaffolds. HA powder was melt blended with PCL, a biodegradable polymer. Scaffolds with a controlled pore size of 400 /spl mu/m and a 64% porosity were fabricated. The scaffold morphology and the mechanical properties were(More)
CAD has been traditionally used to assist in engineering design and modeling for representation, analysis and manufacturing. Advances in Information Technology and in Biomedicine have created new uses for CAD with many novel and important biomedical applications, particularly in tissue engineering in which the CAD based bio-tissue informatics model provides(More)
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