A L DE GROOT

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Methods Knowledge, Attitudes, and Practices (KAP) studies were performed in 2008 and 2011 to assess KAP related to HIV, HIV transmission, HIV prevention, HPV, cervical cancer, and WTP in vaccine trials. The 2008 KAP study examined HIV KAP and WTP (399 subjects), while the 2011 pilot study examined HPV KAP and WTP for 51 subjects in the same region of(More)
Results An HIV transmission prevention (MTCTP) program was established in the Sikoro prenatal care clinic (Chez Rosalie) in 2005; the Hope HIV Care Center (Bloc Espoir) was completed in 2008, and GAIA VF established the first ‘primary-care-setting’ HIV treatment program in Mali in 2009. >10,000 pregnant women have been screened for HIV infection, >200 have(More)
Methods An initial study was performed at the Faculty of Medicine (279 subjects) in 2004; a second study was performed in the public markets of Bamako (279 subjects), in 2005, and a third was recently performed in Sikoro, a slum located within the city limits of Bamako, where the GAIA Vaccine Foundation has established an HIV care center (399 subjects). All(More)
HIV genomic sequence variability has complicated efforts to generate an effective globally relevant vaccine. Regions of the viral genome conserved in sequence and across time may represent the "Achilles' heel" of HIV. In this study, highly conserved T-cell epitopes were selected using immunoinformatics tools combining HLA-A2 supertype binding predictions(More)
Methods The MTCTP program at Chez Rosalie was one of the first such programs to be established. Standard finger-stick approaches to testing children for HIV at 18 months resulted in very few children tested, as women frequently did not return to the clinic with their children at this time. In 2010, PCR-testing of newborns was integrated into mothers’(More)
Results 10,471 women were counseled about HIV infection during the study period (average 145/month). An overwhelming majority (99.1%) agreed to HIV testing: 202 (2.15%) were HIV+, of whom 125 (61.9%) accepted MTCTP treatment. Ninety-two HIV+ women delivered at Chez Rosalie. Most used the baby formula provided at the clinic, and a minority chose(More)
Background HIV treatment in Mali is constrained by limited access to HIV experts. In 2009, GAIA Vaccine Foundation’s “Hope Center Clinic” (HCC), a community health center in Mékin-Sikoro, became one of the first “front-line” clinics to offer HIV treatment in Mali. To assess our HIV prevention strategies and prepare for an eventual HIV vaccine trial, we(More)