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Epigenetic states and certain environmental responses in mammals and seed plants can persist in the next sexual generation. These transgenerational effects have potential adaptative significance as well as medical and agronomic ramifications. Recent evidence suggests that some abiotic and biotic stress responses of plants are transgenerational. For example,(More)
The ING1b protein is a type-II tumour suppressor and stoichiometric member of the Sin3 histone deacetylase (HDAC) protein complex in which it acts to target HDAC activity to regulate chromatin structure. Altering ING1 levels by ectopic expression of ING1b in cancer cells promotes apoptosis, whereas altering levels by knockout in normal murine fibroblasts(More)
ING1b is a type II tumor suppressor that is inactive in a broad range of cancers, many of which show resistance to apoptosis. It is a stoichiometric member of histone deacetylase (HDAC) complexes 1 and targets them to the H3K4Me3 histone mark 2 to regulate transcription. ING1b's effects on transcription are then thought to affect cellular functions relevant(More)
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