A. Karam

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In neurodegenerative disorders caused by polyglutamine (polyQ) expansion, polyQ toxicity is thought to trigger a linear cascade of successive degenerative events leading to neuronal death. To understand how neurons cope with polyQ toxicity, we studied a Spinocerebellar ataxia 7 (SCA7) mouse which expresses polyQ-expanded ATXN7 only in rod photoreceptors. We(More)
Huntington's disease (HD) is a neurodegenerative disorder caused by the toxic expansion of polyglutamine in the Huntingtin (HTT) protein. The pathomechanism is complex and not fully understood. Increasing evidence indicates that the loss of normal protein function also contributes to the pathogenesis, pointing out the importance of understanding the(More)
In container terminals, discharging and loading of vessels are critical planning decisions which highly depend on the interaction between the quay cranes and internal trucks, they also have a significant impact on the terminal performance and revenue. Decisions on the assignments of quay cranes and internal trucks to the berthed vessels are typically made(More)
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