A. K. Sahai

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The present study was conducted to investigate the possible interaction between low doses of nicotine and pentylenetetrazole (PTZ) in vivo and also to evaluate the influence of nicotine on the antiseizure efficacy of topiramate and sodium valproate in the PTZ-induced seizure model in mice. Graded dose-response study with nicotine showed the CD50 value for(More)
The present study aimed at establishing two models of experimental seizures by combination treatment with subconvulsive doses of PTZ and kainic acid in adult male mice and evaluating the modulatory role of cerebroselective dihydropyridine calcium channel blocker, nimodipine. The CD50 +/- SEM value for PTZ was found to be 20.00 +/- 0.92 mg/kg, ip in kainic(More)
INTRODUCTION Tobacco smoking is a widespread phenomenon, and nicotine is the addictive component of tobacco. Nicotine acts through nicotinic cholinergic receptors and has been associated with different types of psychophysical disorders in human beings. The present study had explored the proconvulsive action of nicotine and its effect on the antiseizure(More)
The nonlinear convectively coupled character of the summer monsoon intraseasonal oscillation (ISO) that manifests in its event-to-event variations is a major hurdle for skillful extended-range prediction of the active/break episodes. The convectively coupled character of the monsoon ISO implies that a particular nonlinear phase of the precipitation ISO is(More)
The distribution of neuronal nitric oxide synthase (nNOS) containing neurons and fibers in subnuclei of the nucleus tractus solitarii (NTS) in the squirrel monkey, Saimuri sciureus, was investigated by nNOS immunohistochemistry and nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase histochemistry. Generally, the staining pattern of nNOS and(More)
Coupled climate modeling has become one of the most challenging fields with the development of multicore architectures and its importance in daily weather and climate predictions. At IITM, ‘PRITHVI’ cluster (~70TF), NCEP Climate Forecast System (CFS) and its atmospheric component (GFS) have been installed on IBM Power6 architecture.(More)
BACKGROUND Experimental studies have found several calcium channel blockers with anticonvulsant property. Flunarizine is one of the most potent calcium channel blockers, which has shown anticonvulsant effect against pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures. However, further experimental and clinical trials have shown varied(More)
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