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Continuous intravenous infusion of prostacyclin (PGI2) was carried out for 30 to 120 min at the rates 25, 50, 75, 100 ng/kg/min in 149 experiments in 30 anesthetized dogs. PGI2 caused significant dose-dependent rise in heart rate, cardiac output, stroke volume and mean coronary artery blood flow. At the same time arterial blood pressures, total peripheral… (More)