A. Jon Stoessl

Zbigniew K. Wszolek3
Owen A. Ross3
3Zbigniew K. Wszolek
3Owen A. Ross
2Ludwig Gutmann
2Donald B. Calne
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Perry syndrome consists of early-onset parkinsonism, depression, severe weight loss and hypoventilation, with brain pathology characterized by TDP-43 immunostaining. We carried out genome-wide linkage analysis and identified five disease-segregating mutations affecting the CAP-Gly domain of dynactin (encoded by DCTN1) in eight families with Perry syndrome;(More)
Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of(More)
Idiopathic basal ganglia calcification (IBGC) is characterized by bilateral calcification of the basal ganglia associated with a spectrum of neuropsychiatric and motor syndromes. In this study, we set out to determine the frequency of the recently identified IBGC gene SLC20A2 in 27 IBGC cases from the Mayo Clinic Florida Brain Bank using both Sanger(More)
  • Lisa Kuramoto, Jacquelyn Cragg, Ramachandiran Nandhagopal, Edwin Mak, Vesna Sossi, Raul de la Fuente-Fernández +2 others
  • 2013
BACKGROUND To date, statistical methods that take into account fully the non-linear, longitudinal and multivariate aspects of clinical data have not been applied to the study of progression in Parkinson's disease (PD). In this paper, we demonstrate the usefulness of such methodology for studying the temporal and spatial aspects of the progression of PD.(More)
unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Dr. Ali Rajput and the program he personally established at the University of Saskatoon, starting in the late 1960s, have contributed immeasurably to our current knowledge of Parkinson's disease (PD) and related movement disorders. One could(More)
We present a novel analysis method for positron emission tomography (PET) data that uses the spatial characteristics of the radiotracer's distribution within anatomically-defined regions of interest (ROIs) to provide an independent feature that may aid in characterizing pathological and normal states. The analysis of PET data for research purposes(More)
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