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1. Glutamate, acetylcholine (ACh), and bicuculline were delivered by iontophoretic pipettes to the 545 neurons described in the preceding paper. Their response properties were examined to determine the effect of these compounds on the behavior of neurons in rat somatosensory cortex. 2. The responses to glutamate covered a broad range. Some cells were(More)
Markov-modulated models for equity prices have recently been extensively studied in the literature. In this paper, we apply some old results on the Wiener–Hopf factorization of Markov processes to a range of option-pricing problems for such models. The first example is the perpetual American put, where the exact (numerical) solution is obtained without(More)
We report the absence of functional parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptors (PTH/PTHrP receptor) in Blomstrand chondrodysplasia, a genetic disorder characterized by advanced endochondral bone maturation. Analysis of PTH/PTHrP receptor genomic DNA from a patient with Blomstrand chondrodysplasia demonstrated that the patient was(More)
Neurons located in the medial septum-nucleus of the diagonal band (vertical limb) area and antidromically activated by electrical stimulation of the fimbria were recorded in urethane anesthetized rats. Forty-five percent of these septo-hippocampal neurons (SHNs) discharged rhythmically in short bursts (mean burst frequency, 4 Hz). They were antidromically(More)
We describe a patient with Blomstrand chondrodysplasia, a lethal genetic disorder characterized by extremely advanced endochondral bone maturation, in whom a homozygous missense mutation is present in the gene coding for the PTH/PTHrP receptor that leads to the substitution of a proline for a leucine in the N-terminal portion of the receptor (P132L).(More)
The topographic organization of basal forebrain neurons projecting to the rat cerebral cortex was investigated using the retrograde transport of horseradish peroxidase (HRP). HRP injections in cingulate and occipital cortices labeled neurons in the nucleus of the diagonal band of Broca. In contrast, injections in the frontal cortex labeled mostly neurons in(More)
Various stressful manipulations in rats (cold-water swim, electric foot-shock administration, imparied access to food reward) were found to reduce the convulsant potency of drugs which interfere with GABA or benzodiazepine central processes. The convulsant threshold dosages of picrotoxin (0.4 mg/ml) or pentetrazol (10 mg/ml) administered after the stress by(More)
In rats anaesthetized with either urethane, pentobarbital or fluothane the effects of acetylcholine, cholinergic agonists and antagonists (applied by iontophoresis) were studied on single cortical neurons of first somatosensory region. The laminar distribution of the neurons excited by acetylcholine was determined by the reconstruction of each electrode(More)
Neurons located in the ventromedial globus pallidus (nucleus basalis) and substantia innominata, that were antidromically driven by electrical stimulation of the frontoparietal cortex, were recorded in the urethane anesthetized rat. The basalocortical neurons (BCNs) were antidromically driven with latencies of 1.1-13.5 ms, giving conduction velocities of(More)
Septo-hippocampal neurons (SHNs) were recorded from the medial septum-diagonal band area of rats anaesthetized with either urethane or fluothane. They were identified by their antidromic response to the electrical stimulation of the fimbria. Their responses to peripheral somatic noxious and non-noxious stimulation were studied. Non-noxious natural(More)