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Studies undertaken to compare the effects of Ap4A and ATP on altering intrasynaptosomal Ca2+ levels from deermouse brain reveal that both ligands induce a rapid influx of extracellular Ca2+. The Ca2+ profile elicited by 167 microM Ap4A is "spike-like" (half-time for decline to baseline, 19.1 +/- 1.2 sec), in contrast to the gradual decline observed with ATP(More)
Binding of adenosine 5',5" '-P1,P4-tetraphosphate (Ap4A) to a purinoceptor on nerve growth factor-differentiated (NGF) pheochromacytoma (PC12) cells modulated cytosolic Ca2+ levels. Both Ap4A and ATP elicited an influx of extracellular Ca2+, but both the sensitivity of the response and the flux profile were different. Preincubation of the PC12 cells with(More)
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