A. J. Moonen

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OBJECTIVE Achalasia is a chronic motility disorder of the oesophagus for which laparoscopic Heller myotomy (LHM) and endoscopic pneumodilation (PD) are the most commonly used treatments. However, prospective data comparing their long-term efficacy is lacking. DESIGN 201 newly diagnosed patients with achalasia were randomly assigned to PD (n=96) or LHM(More)
The mechanical properties of the esophagogastric junction (EGJ) are of major importance for the competence of the EGJ. Although manometry reliably measures sphincter pressure, no information is provided on distensibility, a crucial determinant of flow across the EGJ. Recently, a new technique, impedance planimetry, was introduced allowing accurate(More)
Achalasia is a rare motility disorder of the esophagus characterized by the absence of peristalsis and defective relaxation of the lower esophageal sphincter. Patients present at all ages with dysphagia and regurgitation as main symptoms. The diagnosis is suggested by barium swallow and endoscopy and confirmed by manometry. Because there is no curative(More)
Achalasia is the best characterized primary esophageal motility disorder of the esophagus and typically presents with absent peristalsis of the esophageal body and a failure of the lower esophageal sphincter to relax upon swallowing on manometry, associated with progressively severe dysphagia, regurgitation, aspiration, chest pain, and weight loss. The(More)
OPINION STATEMENT Achalasia is a primary esophageal motor disorder of the esophagus that is characterized by the absence of esophageal peristalsis and a failure of the lower esophageal sphincter (LES) to relax upon swallowing. The defective relaxation leads to symptoms of dysphagia for solids and liquids, regurgitation, aspiration, chest pain, and weight(More)
OBJECTIVE To gain insight into the role of consultation in palliative sedation. DESIGN Retrospective analysis. METHOD All consultation records of the Palliation Team Midden Nederland (PTMN) from 1 November 2005 to 31 October 2006 were analysed. If palliative sedation was mentioned in the record, the following variables were listed: character of the(More)
We extract information about collisions of ultra-cold ground-state rubidium atoms from observations of a g-wave shape resonance in the 85Rb + 85Rb system via time-independent and time-dependent photoassociation. The shape resonance arises from a quasi-bound state inside a centrifugal barrier that enhances the excitation to the bound electronically excited(More)
and high-resolution manometric techniques, it is possible to examine the dynamic response of the LES in treated achalasia patients for longer intervals, particularly in response to bolus challenges. In my experience, one often finds that a low “resting” LES pressure can increase quite dramatically and obstructively in response to luminal distension of(More)
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