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The p53 tumor suppressor is a transcription factor that can activate the expression of some genes and repress the transcription of others. The protein appears to be dispensable for normal murine… (More)
Embryonal carcinoma (EC) cells are stem cells of teratocarcinomas. Many lines of EC cells can differentiate into a wide spectrum of cell types and are termed pluripotent. Some EC cell lines, however,… (More)
The p53 tumor suppressor gene is the most commonly mutated gene in human cancers and, although mutation leads to loss of p53 suppression of cell growth, it can also result in new functions which… (More)