Learn More
In some cochleae, the number and kinetic properties of Ca2+-activated K+ (KCa) channels partly determine the characteristic frequency of each hair cell and thus help establish a tonotopic map. In the chicken's basilar papilla, we found numerous isoforms of KCa channels generated by alternative mRNA splicing at seven sites in a single gene, cSlo. In situ(More)
How Hearing Happens Minireview hair-cell loss resulting from any of a hundred or so ge-A. J. Hudspeth netic conditions. Hair cells are vulnerable to infections Howard Hughes Medical Institute and to such pharmaceutical agents as aminoglycoside and Laboratory of Sensory Neuroscience antibiotics and the chemotherapeutic agent cisplatin. The Rockefeller(More)
The auditory-brainstem response (ABR) to short and simple acoustical signals is an important clinical tool used to diagnose the integrity of the brainstem. The ABR is also employed to investigate the auditory brainstem in a multitude of tasks related to hearing, such as processing speech or selectively focusing on one speaker in a noisy environment. Such(More)
The brain's analyses of speech and music share a range of neural resources and mechanisms. Music displays a temporal structure of complexity similar to that of speech, unfolds over comparable timescales, and elicits cognitive demands in tasks involving comprehension and attention. During speech processing, synchronized neural activity of the cerebral cortex(More)
  • 1