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Mesenchymal stem cell (MSC) differentiation can be influenced by biophysical stimuli imparted by the host scaffold. Yet, causal relationships linking scaffold strain magnitudes and inlet fluid velocities to specific cell responses are thus far underdeveloped. This investigation attempted to simulate cell responses in a collagen-glycosaminoglycan (CG)(More)
Tissue engineering often involves seeding cells into porous scaffolds and subjecting the scaffold to mechanical stimulation. Current experimental techniques have provided a plethora of data regarding cell responses within scaffolds, but the quantitative understanding of the load transfer process within a cell-seeded scaffold is still relatively unknown. The(More)
Artificial tissue growth requires cells to proliferate and differentiate within the host scaffold. As cell function is governed by mechano-sensitive selection, tissue type is influenced by the microscopic forces exposed to the cells, which is a product of macroscopically straining the scaffold. Accordingly, the microscopic strain environment within a CG(More)
BACKGROUND The fluid load support fraction (W(F)/W(T)) can be used to define the mechanical contribution of the interstitial fluid (W(F)) to the total force (W(T)) in the deformation of cartilage. Traditionally, W(F)/W(T) is calculated using complex experimental setups or time-consuming micromechanical poroelastic Finite Element (FE) simulations. AIM To(More)
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