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The effect of anticholinesterases physostigmine and galanthamine on spontaneous and intraarterial bradykinin-induced bioelectrical activity in the ventrolateral tracts of the spinal cord in spinal rats was studied. Physostigmine (1, 2 and 4 micrograms) and galanthamine (25, 50 and 100 micrograms) administered intrathecally were found to produce… (More)
Two series of experiments were performed to study the effects of oxotremorine (5, 10 and 20 micrograms/kg), arecoline (0.25, 0.5 and 1.0 mg/kg), pilocarpine (5, 10 and 20 mg/kg) and aceclidine (0.25, 0.5 and 1.0 mg/kg) injected intravenously on nociceptive transmission in the spinal cord of spinal rats. It was established that the m-cholinomimetics inhibit… (More)