A. I. Vengerovskii

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Silymarin (70 mg/kg) and succinic acid (50 mg/kg) reduce blood glucose and cholesterol concentrations, inhibit LPO, and correct oxidative phosphorylation disturbances in liver mitochondria in experimental diabetes mellitus induced by injection of streptozotocin (65 mg/kg) in rats.
Acute pancreatitis in rats caused by cooling of the pancreas with chloroethyl is characterized by the development of focal necrosis and activation of lipid peroxidation in the liver, activation of blood aminotransferase and acid and alkaline phosphatase, and increase in total and indirect bilirubin concentrations.
Choline-positive neuroprotectors citicoline and choline alfoscerate decreased blood concentration of protein S100 in clinical trial on 52 patients in the first days after acute ischemic stroke. Neuroprotective therapy has also produced stabilization of blood-brain barrier.
The influence of vinpocetine (cavinton) on endothelium function in 87 patients with chronic cerebral ischemia has been studied. Vinpocetine exerts an endothelium protective effect which appears as a partial renewal of endothelium-dependent vasodilatation and inhibition of rejection of Willebrand factor during arteriovenous occlusion test. Leveling of(More)
In chronic hepatitis induced by long-term CCl4 administration to rats, there was largely an increase in the formation of malonic dialdehyde and Schiff bases, an elevation of glycosaminoglycans and hydroxyproline in collagen fractions, and proliferation of hepatic fibrous tissue. Therapy of CCl4-induced hepatitis with the hepatoprotective antioxidants(More)
The experiments on rats with a model acute pancreatitis showed that hepatoprotectors containing phospholipids (eplir and essentiale) improve the parameters of metabolism and the functions and histological characteristics of the pancreas and liver. Both drugs produced an antioxidant effect, decreased the activity of alpha-amylase, lipase, enzymes of hepatic(More)
The experiments on rats with a model toxic hepatitis induced by tetrachloromethane showed that hepatoprotectors containing phospholipids (eplir and essentiale) introduced in combination with prednisolone decrease the immunodepressant effect of this glucocorticoid, as manifested by a decrease in the atrophy of thymus and an increase in the amount of blood(More)
Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the(More)