A. I. Tochilkin

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Vanadium compounds as insulin mimics with promising therapeutic properties are reviewed. The biological effects of both inorganic forms of vanadium and vanadyl organic complexes are decried for various animal models. These effects include hypoglycemic and insulin reserve actions, insulin sensitivity enhance, cholesterol lowering and other manifestations.(More)
The search for new selective inhibitors of monoamine oxidase (MAO) among quinoline derivatives has taken on special interest in recent years in connection with the modern achievements in the study of the chemistry of natural modulators of MAO activity [3]. Continuing the work along this line we synthesized compounds in which the quinoline ring is bonded to(More)
Chemical compounds that influence MAO activity play an important role in the study of this enzyme and in the regulation of its functions in the human and animal organism [i$ 6~ 7, 84]. MAO inhibitors have proved to be a convenient means of studying the nature and properties of this enzyme, all the more in that MAO, like other membrane-bound enzymes, is(More)
Monoamine oxidase (MAO) inhibitors were among the first drugs that produced a revolution in the second half of the twentieth century. The attention of medical science is now being attracted primarily by reversible, selective-acting MAO inhibitors, which to a substantial degree lack the shortcomings characteristic of the "first-generation" MAO inhibitors,(More)
i. V. A. Burobin, N. V. Likhacheva, and G. E. Abgafarova, Lab. Delo, No. ii, 650-653 (1978). 2. V. K. Gorshkova, M. I. Naidenova, T. P. Novozheeva, et al., Current Topics in Pharmacology and the Search for New Drugs [in Russian], Tomsk (1986), pp. 15-19. 3. E. M. Dumenova and A. S. Saratikov, Khim.-farm. Zh., No. 5, 121-123 (1982). 4. M. V. Korablev and P.(More)
A simple and highly specific method for estimating the cholesterol esterase activity is suggested. Cholesterol esterase (EC 3.1.1.13) is incubated with the emulsified substrate, cholesteryl-o-coumarate, at pH 6.6 to yield o-coumaric (trans-2-hydroxycinnamic) acid detected fluorimetrically (lambda exc 363 nm, lambda em 494 nm) at pH 10.4. The fluorescence(More)
In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) was prepared and its potential as a novel hypoglycemic agent was studied in the streptozotocin-diabetic rats. We show that the oral administration of bis(L-malato)oxovanadium(IV)(More)
Cytotoxic and antitumor activity of the biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) (VO(mal)2) was investigated in comparison with inorganic vanadium(IV) compound--vanadyl sulfate (VOSO4) and also with oxovanadium monocomplex with L-malic acid (VO(mal)) and vanadyl biscomplex with acetylacetonate. In this purpose the effect of(More)
The pharmacological approaches to the treatment of type 2 diabetes mellitus were reviewed. Special attention was paid to the new therapeutic agents that are able to decrease plasma glucose levels. The possible mechanisms of the hypoglycemic effects are discussed. Briefly, repaginide, nateglinede and alpha-glucosidase inhibitors prevent postprandial(More)