A I El-Sakka

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OBJECTIVE To determine the role of transforming growth factor beta (TGF-beta), one of the cytokines known to induce tissue fibrosis, in the induction of a Peyronie's-like condition, and to produce an animal model for the further study of Peyronie's disease. MATERIALS AND METHODS Twenty-four adult male Sprague-Dawley rats were divided into two groups: in(More)
PURPOSE Increased TGF-beta1 protein expression in tunica albuginea has been found to be associated with Peyronie's disease. The present study is designed to investigate whether surgical trauma induces TGF-beta up-regulation and histological changes in rat penis. MATERIALS AND METHODS Thirty-two adult male Sprague-Dawley rats were divided into two groups.(More)
PURPOSE We examine the effect of a Chinese herbal medicine mixture on erectile function in a rat model of hypercholesterolemic erectile dysfunction. MATERIALS AND METHODS In this study 32, 3-month-old Sprague-Dawley rats were used. The 8 control animals were fed a normal diet and the remaining 24 were fed 1% cholesterol diet for 4 months. After 2 months(More)
Erectile dysfunction occurs frequently in humans with diabetes mellitus; the molecular basis of this phenomenon is not known. We investigated the effects of diabetes on penile erection, nitric oxide synthase and growth factors expression in an animal model. Forty male rats were divided into two groups: the experimental group (n=30) received intraperitoneal(More)
PURPOSE We evaluate the results of tunical incision and venous patch grafting for correcting penile deformity in Peyronie's disease. MATERIALS AND METHODS In 113 [corrected] patients with symptoms of Peyronie's disease for more than a year indications for surgery included penile shortening, persistent pain, severe curvature, penile narrowing or(More)
We investigated the association between the International Index of Erectile Function (IIEF) and axial penile rigidity parameters in patients with erectile dysfunction (ED). A total of 516 male patients (491 patients with ED and 25 patients without ED) were assessed using IIEF. Patients were assessed for axial penile rigidity (APR) using a digital inflection(More)
We developed a rat model of traumatic arteriogenic erectile dysfunction (ED) for the study of vasculogenic ED. Bilateral ligation of the internal iliac artery was performed on 30 three-month old male Sprague–Dawley rats as an experimental group. The control group consisted of 12 rats which underwent dissection of the internal iliac artery without ligation.(More)
OBJECTIVES Cryoablation of the prostate has been reported to induce impotence as a consequence of cavernosal nerve injury. This study is designed to investigate the early and late effects of cavernosal nerve cryoablation on growth factor expression and erectile function in a rat model. METHODS Forty male rats were divided into two groups (n=20 each). The(More)
PURPOSE We describe our technique of plaque incision and venous patch grafting to correct complex penile deformity associated with Peyronie's disease. MATERIALS AND METHODS Graft material is obtained from the lower and upper saphenous and deep dorsal veins. The configuration, size and number of tunical incisions depend on the site and size of the lesion.(More)
A number of procedures have been developed to correct penile deformity secondary to Peyronie's disease. In many cases, tunica-shortening procedures have had reasonable success. The most popular of these are tunical plication and Nesbit's wedge resection. However, these procedures shorten the penis and do not correct the hourglass deformity.(More)