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The effects of long term (30 days) lithium treatment of various doses on behavioral despair test and on serotonin metabolism in the hypothalamus, midbrain and striatum of rats were examined. Lithium at doses of 0.5, 2 and 5 mEq/kg significantly decreased the duration of immobility. In other words, lithium behaved as an antidepressant drug. Serotonin(More)
The activities of the brain L-asparaginase and angiotensin converting enzyme (ACE), and the plasma cortisol level were found to be decreased in the rats implanted with morphine (M) containing pellets. Even though 10 mg/kg of naloxone (N) itself showed an inhibitory effect on ACE it abolished the inhibitions seen in the M dependent rats five min following(More)
The effects of long term (10 days) treatment of lithium and naloxone on HVA levels of striatum, hypothalamus and frontal cortex in rats were investigated. Lithium (400 mg/l in drinking water) itself had no effect on HVA levels of any region. Naloxone (2 mg/kg) treatment caused significant increases in the levels of HVA in hypothalamus and striatum and(More)
The relationship between cerebrospinal fluid levels of HVA and 5-HIAA and the hypokinetic-rigid symptoms that occurred during oral administration of haloperidol in twenty schizophrenic patients was investigated. Measurement of the silent period in the EMG was used for evaluation of these symptoms. The results support the hypothesis of a positive correlation(More)
The effects of lithium and chlorpromazine chronically administered alone and together on the dopamine metabolism in the rat striatum and frontal cortex were investigated by measurement of the levels of dopamine (DA) and its main metabolite, homovanillic acid (HVA). Long-term chlorpromazine administration caused a significant increase in the striatal DA(More)
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