A. Hematulin

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NBS1 fulfills important functions for the maintenance of genomic stability and cellular survival. Mutations in the NBS1 (Nijmegen Breakage Syndrome 1) gene are responsible for the Nijmegen breakage syndrome (NBS) in humans. The symptoms of this disease and the phenotypes of NBS1-defective cells, especially their enhanced radiosensitivity, can be explained(More)
The use of herbal products as radiosensitizers is a promising approach to increase the efficacy of radiotherapy. However, adverse effects related to the use of herbal medicine on radiotherapy are not well characterized. The present study concerns the impact of Derris scandens Benth extract on the radiosensitivity of Hep-2 laryngeal cancer cells.(More)
NBS1 is a member of the Mre11-Rad50-NBS1 complex, which plays a role in cellular responses to DNA damage and the maintenance of genomic stability. Transgenic mice models and clinical symptoms of NBS patients have shown that NBS1 exerts pleiotropic actions on the growth and development of mammals. The present study showed that after repression of endogenous(More)
Cholangiocarcinoma is a destructive malignancy with a poor prognosis and lack of effective medical treatment. Radiotherapy is an alternative treatment for patients with unresectable cholangiocarcinoma. However, there are limited data on the radiation responsiveness of individual cholangiocarcinoma cells, which is a key factor that influences radiation(More)
Enhancing of radioresponsiveness of tumors by using radiosensitizers is a promising approach to increase the efficacy of radiation therapy. Recently, the ethanolic extract of the medicinal plant, Derris scandens Benth has been identified as a potent radiosensitizer of human colon cancer HT29 cells. However, cell death mechanisms underlying(More)
The Nbs1 protein (nibrin, p95) is a member of the DNA repair/checkpoint complex Mre11/Rad50/Nbs1 (MRN), which plays a critical role in the cellular responses to DNA damage, cell cycle checkpoints, and telomere and genome stability. Many transgenic models in mice and clinical symptoms of NBS patients have clearly shown that Nbs1 exerts pleiotropic actions in(More)
The method suggested in the manuscript uses the idea of the hodograph transformation method, which exchanges the independent and dependent variables. Here a change of the independent variables into dependent variables is applied to first derivatives. For the derivatives one obtains a system of differential equations. Group analysis is applied to this(More)
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