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The effects of the intravenous administration of cocaine (0.05-5.0 mg/kg) on body temperature, heart rate, respiration rate and several unconditioned behavioral categories were ascertained in unanesthetized male rhesus monkeys. Statistically significant increases in body temperature, respiration rate and heart rate occurred only after the largest dosage… (More)
An improved synthesis of norcocaine, a metabolite of cocaine, is reported. Following intravenous administration to a rhesus monkey, respiratory effects were similar to those observed following cocaine treatment. In addition, clonic convulsions, hypothermia, and mydriasis resulted. Norcocaine could be responsible for part of the pharmacological activity of… (More)
In an earlier study, it was found that a 15-day ip postfeeding session d-amphetamine treatment rendered an apparent "tolerance" to the feed intake suppressant effects of fenfluramine. The purpose of the present study was to determine if such d-amphetamine treatment altered the disposition of fenfluramine in a way which might account for this decrement in… (More)
A procedure is described which allows chronic dosing and blood collection from awake monkeys. The procedure involves only minor surgical anesthesia and allows the same vein of the animal to be used several different times with home-cage recuperation periods intervening between sequential chronic catheterizations.
Dermatologists responding to a mail survey supplied 520 prescriptions as examples of prescriptions requiring compounding. A total of 195 different ingredients were used, with an average of 2.5 ingredients per prescription. Anti-inflammatory agents were most frequently used. Brand-name medications were frequently incorporated with other ingredients.